Clinical Trials & Research

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and other diseases, according to a study co-authored by a Rutgers researcher. The study, published in The Proceedings of the National Academy of Sciences (PNAS), describes the
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Outsourcing NHS services to the private sector is associated with reduced quality of patient care and increased rates of deaths from treatable causes, according to an analysis published in The Lancet Public Health journal. Findings from the study suggest increased privatization of health services in England between 2013 and 2020 was linked to higher rates
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Tau hyperphosphorylation is the key characteristic pathological hallmarks of Alzheimer’s disease (AD). Recently studies showed periodontitis and periodontal pathogen are significant risk factors for AD. Treponema denticola (T. denticola), as the main periodontal pathogen of periodontitis, has been reported a possible link with AD, however, the role of T. denticola in AD pathogenesis is still
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In the largest epidemiologic study of arsenic and birth outcomes to date, researchers from the University of Illinois Chicago and collaborating institutions estimated arsenic levels in U.S. private well water sources by county and compared estimates to documented birth outcomes. They found an association between estimated groundwater arsenic concentration and risk of low birth weight.
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Susan G. Komen®, the world’s leading breast cancer organization, is awarding $21.7 million to fund 48 new research projects at 26 distinguished academic medical institutions in the U.S. that are focused on improving patient outcomes – particularly for people with the most aggressive breast cancers, or who have experienced a recurrence or metastasis. With this
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A CDC investigation notice regarding multistate outbreaks of Salmonella infections has been posted: https://www.cdc.gov/salmonella/backyardpoultry-06-22/index.html Key points: CDC and public health officials in several states are investigating multistate outbreaks of Salmonella infections linked to contact with backyard poultry. In total, 219 illnesses have been reported from 38 states, and 27 people have been hospitalized. One in
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A new perspective by researchers from the American Cancer Society (ACS) and the University of Texas Health Science Center at San Antonio shows the high burden of breast cancer mortality in African American (Black) women versus White women began in the United States in the 1980’s. At that time, breast cancer screening (mammography) and treatments
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Bottom Line: The accuracy of diagnostic mammograms differed across racial and ethnic groups, with variation in several measures of diagnostic performance. Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. Authors: Sarah J. Nyante, PhD, associate professor of radiology at the University of
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a major blip in the health, societal and economic well-being of the whole world for more than two years, following its unexpected emergence in December 2019. This beta-coronavirus undergoes transcription in the host cell, giving rise to multiple polyproteins that are cleaved by viral proteases to
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Having shown that diet can influence gene expression, science is starting to find out more about how this happens. According to an article recently published in Food and Chemical Toxicology, a diet supplemented with or deficient in methionine, an essential amino acid abundant in eggs, meat and seafood, affects the expression of genes associated with
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Thought LeadersHenry FingerhutSenior Policy Analyst for Science & InnovationTony Blair Institute for Global Change In this interview, News-Medical speaks to Henry Fingerhut, Senior Policy Analyst for Science & Innovation at the Tony Blair Institute for Global Change, about genomic surveillance and its associated opportunities and challenges. In collaboration with Professor Derrick Crook of Oxford’s Nuffield
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Researchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis. The results are published in Nature Chemical Biology. Our findings indicate a new potential target for treating diabetes, in that
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